Record each void
Write down the time of every urination, day and night.
Urine osmolality profiling for the bladder diary
A missing measurement behind the midnight wake-up.
Osmurix is developing a handheld, home-use urine osmometer that adds objective osmolality profiling to the bladder diary—giving clinicians supplemental data on day-time and night-time urine concentration.
Functional prototype · Not approved or cleared by any regulatory authority · Clinical evaluation ongoing
The diagnostic bottleneck
A demanding diary captures volume. Not cause.
Today, patients are typically asked to complete a frequency–volume chart for three days. The method is clinically useful, but manual recording creates friction and can leave clinicians with an incomplete picture.
- The symptom
- NocturiaWaking during the main sleep period to pass urine—interrupting restorative sleep and quality of life.
- The common driver
- Nocturnal polyuriaThe kidneys produce a disproportionate share of the day’s urine during sleep—commonly more than one-third in older adults.
Measure volume
Collect and manually record the amount of urine passed.
Log every drink
Track fluid type, timing and volume across the same period.
Water or solute diuresis?
Volume alone cannot reveal what is driving the excess urine.
“The diary tells us how much. We still need to know why.”
Only 37%of LUTS diagnoses in a real-world database were based on a bladder diary.1
~2 yearsmean time from symptom onset to first prescribed treatment.1
A growing burden
Nocturia rises sharply with age.
Clinically significant nocturia—two or more night-time voids—affects both men and women, with prevalence approaching one in two among adults over 65.2
~ 1 in 4 aged 46–65~ 1 in 2 aged >65
Prevalence by age and sex
Adults reporting ≥2 night-time voids
Men Women
Bridging the etiological gap
Volume confirms there is too much urine. Osmolality helps reveal why.
Urine is a solution composed of water and dissolved particles. Osmolality measures the concentration of those particles, adding physiological context to urine volume across the day and night.
DiluteWater-dominant pattern
300mOsm/kg H₂O
ConcentratedSolute contribution
Typically <300 mOsm/kg H₂O
Water diuresis
Dilute urine can indicate excess free-water excretion or reduced concentrating activity. Any clinical or treatment implications of this pattern are for the treating clinician to determine.
- Low urine concentration
- ADH-related mechanism may be present
- Requires clinician interpretation
Typically >300 mOsm/kg H₂O
Solute diuresis
More concentrated urine suggests that dissolved solutes contribute to urine production. This can prompt investigation of sodium, urea, glucose and underlying conditions.
- Higher osmotic load
- May point toward OSA or metabolic causes
- Alternative management may be needed
Important: The 300 mOsm/kg H₂O boundary is a clinical heuristic, not a standalone diagnosis or treatment decision. Osmolality must be interpreted with urine volume, timing, medical history and other clinical data.
~5 minper sample
15measurements per profile
The Osmurix approach
A three-day physiological profile, designed for home.
Osmurix combines a portable reader with a proprietary disposable cup to complement the standard diary with objective urine osmolality measurements across the day and night.
01Collect each planned sample at home
02Measure osmolality at the point of care
03Profile diurnal and nocturnal patterns
04Interpret alongside the bladder diary
~40×smaller footprint (design target)
~50×lower equipment cost (design target)
Homeinstead of central-lab logistics
Design targets, not measured product performance. Internal comparison against one representative commercial freezing-point osmometer; not independently verified.
Value across the care pathway
One measurement. Three stakeholder outcomes.
Osmurix is being designed around the people who interpret, deliver and live with nocturia care—not only the instrument on the bench.
01For urologists
Sharper clinical triage
Add an objective water-versus-solute signal as supplemental information alongside the bladder diary, for the clinician to interpret.
Decision clarity02For clinics
Lower-friction adoption
Designed to fit existing outpatient workflows, with collection and measurement carried out at home rather than through a central laboratory.
Workflow-friendly03For patients
Profiling where life happens
Build a three-day physiological profile at home, without repeated central-laboratory visits or cold-chain sample logistics.
Home-based profilingCommercial model in development. Pricing has not been determined and the device is not offered for sale.
Patent-pending tri-modal sensing
Three signals. One osmolality result.
A proprietary combination of electrical, optical and adsorption methods is engineered to resolve the main contributors to urine osmolality in a portable format.
Electrical impedance
Measures conductive solutes, including the signal associated with sodium chloride.
Optical refractometry
Reads refractive index to quantify the remaining dissolved constituents.
Activated-carbon adsorption
Reduces large-molecule interferents so the optical signal can be interpreted more precisely.
mOsm/kg H₂O
Urine osmolality
A clinically familiar measurement, generated without freezing-point instrumentation.
Patent applications filed across Singapore, the United States, Europe, Japan and China.Exclusive licensing from the originating research institutions is in progress
Analytical and early clinical evidence
Measured against a laboratory reference method.
The underlying method has been tested across a broad sample set, while the integrated handheld prototype is now being evaluated in an ongoing clinical study at a Singapore public hospital.
Method validationBenchtop
R² = 0.996correlation with the hospital laboratory reference
224urine samples
94.4% ± 5.0%mean accuracy
100–1,200mOsm/kg H₂O evaluated range
Early integrated-device dataHandheld
R² = 0.994correlation with the hospital laboratory reference
24valid urine samples
93.0% ± 8.1%mean agreement
96%within ±50 mOsm/kg H₂O
Clinical evaluation is ongoing at a Singapore public hospital.
These early integrated-device results are encouraging but are based on a small initial sample. The study is expanding the analytical-accuracy dataset required for product development and regulatory submission.
Watch and understand
Two short explainers. One clearer clinical story.
Begin with the burden of the midnight wake-up call, then see how urine osmolality adds the missing physiological dimension.
01 · The challenge
The Midnight Wake-Up Call
02 · The insight
Understanding Urine Osmolality
Clinical sources and claim notes
References- Oelke M et al. Nocturia is often inadequately assessed, diagnosed and treated by physicians. Int J Clin Pract. 2016.
- Vaughan CP et al. Differences in the association of nocturia and functional outcomes of sleep by age and gender. Clin Ther. 2016.
- Jhaveri J et al. The economic burden of nocturia on the U.S. health care system and society. J Manag Care Spec Pharm. 2019.
- Weiss JP et al. Excessive nocturnal urine production is a major contributing factor to the etiology of nocturia. J Urol. 2011.
- Hashim H et al. International Continence Society report on terminology for nocturia and nocturnal lower urinary tract function. 2019.
- Monaghan TF et al. Diagnosing nocturnal polyuria from a single nocturnal urine sample. Eur Urol Focus. 2020.
- Kamel KS et al. Use of urine electrolytes and urine osmolality in clinical diagnosis. 2021.
- Osmurix analytical and prototype performance figures are company data from ongoing development and hospital-linked evaluation; sample sizes and status are stated alongside each result.
Collaborate with Osmurix
Help add objective osmolality data to nocturia assessment.
We welcome conversations with clinical sites, research collaborators, strategic partners and investors.